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5th Hybrid Modeling Workshop (July 1st - July 3rd, 2020)

Due to the COVID-19 outbreak, the workshop will be postponed 

The Novasign hybrid modeling workshop 2020 will take place from July 1st to July 3rd at the University of Natural Resources and Life Sciences (BOKU) in Vienna. During these three days, an intense workshop will cover current topics about applying hybrid models for bioprocess development. Connect to experts from academia and industry and learn how to apply similar strategies for your bioprocesses.

Why hybrid modeling?

Other than in the small molecule business, bioprocesses deal with a high number of unknown uncertainties. Therefore, it is difficult to describe bioprocesses solely with first-principles or mechanistic questions because the underlying mechanistic and components are not fully understood or described. Hybrid models bridge the gap between process knowledge which is available for decades and machine learning tools that help to understand underlying correlations. It will be shown how hybrid models can help to not only understand your bioprocesses in a better way but also to speed up bioprocess development.

Who should attend?

The workshop is a great opportunity for everyone who wants to first get in touch with the subject of modeling and particular hybrid modeling or to educate oneself in more detail. Basic knowledge and a modeling background are not mandatory. The provided program is suited for every level of knowledge, regardless of being a beginner in (hybrid) modeling or already possessing in-depth knowledge. Therefore, this workshop is directed and recommended for everyone, e.g., (PhD) students, scientists in academia and the industry, who is interested in modeling to enhance the efficiency of bioprocesses and to increase the bioprocess modeling knowledge.

“The presentation and tools provided at the workshop were excellent.
Are there any dates set for the 5th Hybrid modeling workshop?”


participant of the Hybrid Modeling Summer School 2019

complete Feedback here and here

Which Topics will be covered?

The course will start with the basic concepts of unsupervised machine learning, supervised machine learning, non-parametric, parametric and hybrid modeling, elucidated with simple examples. Within this three days course, detailed solutions about daily problems, like optimization of single-unit operations but also considerations on how to design and model fully integrated continuous bioprocesses will be explained. Current emerging topics such as process characterization, development, optimization and Digital Twins according to the QbD and PAT principles will be understood and accessible for basic and industrial applications. This broad range of topics provides the participants the needed knowledge to apply hybrid models on their own in their respective fields after the end of the hybrid modeling workshop.

What will you learn?

  • Why modeling of bioprocesses is a key for a better understanding and faster process development

  • The differences between unsupervised, supervised, parametric, non-parametric and hybrid modeling and where to apply each method demonstrated with use-cases

  • Hybrid model structures and ways how to implement them in your daily development

  • Different types of soft-sensor concepts, applications, pros and cons

  • Why advanced process control is the next step and how such concepts can be implemented

  • How Digital Process Twins for different unit operations can be created using hybrid models as a basis


The course contains both, basic lectures to get in touch with the topic and also advanced insights on how hybrid modeling can be applied for bioprocesses. Many detailed case studies will be presented to elaborate on the advantages of hybrid modeling. Apart from the theoretical lectures, almost half of the workshop is spent on detailed hands-on for the participants to learn the basics in data preprocessing, visualization and modeling. Therefore, detailed modeling of both upstream and downstream unit operations will be covered to further strengthen the skills of the participants. Supervisors will support the participants during the hands-on and data analysis sessions. 

Lecturers (more to be announced)

Mark Duerkop Dürkop parametric, non-parametric, semi-parametric, hybrid models

Mark Dürkop

Basic modeling concepts to apply hybrid modeling for bioprocess development

Parametric, non-parametric, hybrid models, supervised, unsupervised, why modeling makes a difference

Rui Oliveria hybrid modeling theory

Rui Oliveira

Detailed hybrid modeling theory

Possible hybrid modeling configurations, model identification, superposition, batch to batch control

Alois Jungbauer Continuous integrated manufacturing

Alois Jungbauer

Continuous integrated manufacturing

Hybrid modeling enables detailed insights into residence time distributions and batch definitions

Benjamin Bayer Intensified design of experiments (iDoE) in upstream development

Benjamin Bayer

Intensified design of experiments (iDoE) in upstream development

Using hybrid models and iDoE to significantly speedup bioprocess development

Maximilian Krippl Hybrid models and digital process twins for TFF and SP-TFF

Maximilian Krippl

Hybrid modeling in Crossflow Filtration

Hybrid models and digital process twins for TFF and SP-TFF

Roger Dalmau Diaz Hybrid modeling Toolbox

Roger Dalmau-Diaz

Hybrid modeling toolbox

Introduction to the hybrid modeling toolbox to solve bioprocess related problems

Further opportunities around the workshop

During the hands-on part of the workshop, there will be the 'Novasign hybrid modeling challenge' at which participants can attend and prove their learnings and skills to develop a hybrid model with a provided data set. All participants can submit the performance of their best hybrid model in a sheet, in which they will be ranked, to also gain honor and visibility outside of the classroom. Participants will also receive a free but time-limited version of the full Novasign-Hybridmodeling Toolbox which can be used for individual modeling purposes.

Further, the organized dinner events of the first two workshop days already allow short guided trips through the beautiful city of Vienna to collect some impressions. Especially in summer, the city has many (outdoor) activities to offer with its high amount of museums, green areas and due to its location next to the Danube and Donauinsel. Most of these are for free and a great opportunity to visit, in case the trip to our workshop is prolonged for the weekend. It is not pure coincidence that Vienna was voted the most livable city for ten times in a row, but we recommend to experience this on your own.

Registration Fees

Terms and Conditions

Registration includes:

The registration fee includes the three days program, the supporting information as paper and electronic formats, lunch and coffee breaks, internet access (WiFi), social program after the course on the first and second of July. It does not include VAT, travel costs, accommodation or catering other than indicated.

Confirmation of registration:

Confirmation of registration will be provided to each participant after complete payment of the course fee.

Limitations of registrations:

A minimum of 10 and a maximum of 25 participants will be accepted.

Cancellation Policy:

Cancellation of registration must be submitted to Cancellations made after 15th May 2020 will be subject to a 50% cancellation fee. Cancellations after 5th June 2020 will be subject to the total fee. In case the participant can not attend,  an alternative candidate can always be sent without penalty but a request has to be sent to

In case the course has to be canceled, a full refund will be made.

Confirmation of participation:

Participants will receive an attendance certificate of excellence for participation.

Venue and further information

The entire workshop will take place in the conference rooms 12 and 13 (red dots) at the University of Natural Resources and Life Sciences (BOKU)

Adress: Muthgasse 11, 1190, Vienna, Austria

Access to University of Natural Resources and Life Sciences and Novasign Vienna for the hybrid modeling workshop and summer schoolboku.jpg
  • All participants are encouraged to bring their own laptop

  • For the hands-on part of the workshop, the Novasign hybrid modeling toolbox will be used and therefore installed in the participants' personal computers

  • Note: The Novasign hybrid modeling toolbox

    • runs only on Windows operating systems

  • a limited number of Windows computers can be provided if necessary email to


There are some hotels  very close to the campus (< 15 minutes):

ibis Styles Wien City Hotel or H-Hotel Vienna

However, the campus can easily and directly be reached using public transportation (Metro U4).

So every hotel close to the U4 might be a good choice.

Looking forward to a great event and to meet

you in person in the beautiful city of Vienna!

sponsors of the workshop

Zeta Sponsor of the hybrid modeling workshop and summer school 2020 Vienna
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